Formulation and development of liposomal gel for topical drug delivery system suraj r. The optimized batch of gels showed good mechanical and physicochemical properties. Clinical 149 therapeutic equivalence studies are in principle necessary, but other models may be used or developed. Formulation and evaluation of microemulsion based luliconazole gel for topical delivery panchaxari mallappa dandagi, pratibha pandey, anand panchakshari gadad, vinayak shivamurthy mastiholimath department of pharmaceutics, kle college of pharmacy a constituent unit of kaher, nehru nagar, belagavi, karnataka, india. The use of topical fluconazole in the treatment of skin diseases with various formulations including lecithinbased organogel, jadhav et al. It can be concluded that luliconazole microemulgel prepared with linseed oil and sodium alginate can be a choice for topical. Formulation and in vitro evaluation of carbopol 934based modified clotrimazole gel for topical application muhammad ubaid1, sadaf ilyas1, sadullah mir2, abida k. Topical and transdermal drug products the topicaltransdermal ad hoc advisory panel for the usp performance tests of topical and transdermal dosage forms. The term topical drug products refers to all formulations applied to the skin except transdermal delivery systems tds or transdermal patches that will be addressed separately.
Rheological characterization of topical carbomer gels neutralized to different ph mohammad t. Formulation and evaluation of curcumin gel for topical. Introduction drug products topically administered via the skin fall. Formulation and in vitro evaluation of carbopol 934based. Topical diclofenac may be preferred over the formulary topical rubefacients because of their greater evidence of safety and efficacy. But these hydrogerl based systems can be vanished or. Disadvantages of topical nsaid formulations are primarily related to local skin irritation as discussed later and difficulty in formulation development. The gel was prepared from carbopol and 5% of borneol. Feb 01, 2020 diclofenac sodium topical gel is indicated for the relief of the pain of osteoarthritis of joints amenable to topical treatment, such as the knees and those of the hands. Benzaclin topical gel 2g was applied topically to the face and back twice daily for four and a half 4. A gel is a solid, jellylike material that can have properties ranging from soft and weak to hard and tough. Formulation, characterization, and clinical evaluation of. Quantifiable loq1ngml clindamycin plasma concentrations were obtained.
New topical therapeutic options need to offer higher efficacy and better patient acceptability, including easier application, to reduce treatment burden and enhance patient adherence. Formulation and evaluation of antibacterial creams and. Draft guideline on quality and equivalence of topical products. Topical gel, precutaneous absorption, emulgel, hydrogel. Evaluation of topical gel bases formulated with various essential. Introduction topical gel is a localized drug delivery system, skin. In antiinflammatory studies done by carrageenan induced rat paw oedema method in wistar albino rats, antiinflammatory effect of crb, hpc and standard gel formulations were significantly different from control group p formulation f1 represents greater zone of inhibition 38 mm as compared to pure gel 34 mm and showed acceptable stability profile. Topical antiinflammatory activity of gel was also evaluated. Both types of developed topical gel formulations were free of skin irritation. To formulate topical gels containing various essential oils and. Islam, 1nar rodrguezhornedo, susan ciotti,2 and chrisita ackermann1,3 received january 10, 2004. Formulation and evaluation of miconazole nitrate as a cubosomal topical gel introduction miconazole nitrate is an antifungal drug that inhibits the enzyme cytochrome p450 cyp51 14. The topical gel formulations for correspondence overcome the above disadvantage since the email. Original article formulation and evaluation of microemulsion.
Nanoemulsion and nanoemulgel as a topical formulation. Formulation and evaluation of fluconazole proniosomal gel. Aceclofenac has been shown to have potent analgesic and antiinflammatory activities, similar to indomethacin and diclofenac and due to its. Gel formulation provides better application property and stability in comparison to cream and ointment. Us6261574b1 cream formulation for topical application. For a drug to be effective when applied topically, the drug molecules must be small topical 45 3. Topical gel preparation has remains one of the most popular and important pharmaceutical dosage forms. Semisolid formulation in all their diversity dominate the system for topical delivery, but foams, spray, medicated powders, solutions, as well as medicated adhesive systems are also in use. Voltaren gel has not been evaluated for use on the spine, hip, or shoulder. The primary objective of this study is to perform detailed and extensive rheological characterization of rheology.
In order for topical emulsions to function effectively they require certain functional excipients. Delivery of drugs to the skin is an effective and targeted therapy for local dermatological disorders. In order to bypass these disadvantages, the gel formulations have been proposed as topical application. Preparation and evaluation of minoxidil gels for topical. Topical nsaid formulations pain medicine oxford academic. Topical gel formulations provide a suitable delivery system for drugs because they are less greasy and can be easily removed from the. The prepared formulation was subjected to physical characterization and physicalchemistry assessment.
If a proposed generic drug product does not use microsphere technology, or if the formulation contains microspheres that are substantially different from that of the reference listed drug rld, then a drug stability test in presence of benzoyl. A gel is a solid or semisolid system of at least two constituents, consisting of a condensed mass enclosing and interpenetrated by a liquid. We are committed to maintaining the highest level of quality. Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model 495 quality control of topical herbal gel formulation estimation of active constituents in gel formulation net content each formulation 1 g was taken in a 50 ml volumetric flask and made up to volume with methanol and. A wide choice of vehicles ranging from solids to semisolids form has been used for skin care and topical treatment of dermatological disease, high molecular weight water soluble polymers of hydroxypropyl methylcellulose hpmc, carbapol 934p, sodium. Diclofenac sodium topical gel has not been evaluated for use on the spine, hip, or shoulder. Kanwal1, ahmad 1nawaz1, amna shah1 and ghulam murtaza. Optimized formulation f1 represents greater zone of inhibition 38 mm as compared to pure gel 34 mm and showed acceptable stability profile. Department of pharmaceutics and industrial pharmacy, faculty of pharmacy, modern. A topical gel has been developed using carbapol 940, propylene glycol, sodium lauryl sulphate. Introduction a gel is a twosegment, cross connected threedimensional system comprising of auxiliary materials blended by an.
More recently, a topical gel formulation will be introduced specifically for the treatment of localized painful and inflammatory condition, such as soft tissue musculoskeletal disorders and osteoarthritis. Dispensed in packs of either three or five tubes of 100 g of topical diclofenac gel 1%, the patient uses a supplied dosing card to apply each dose. Most of the topical preparations are used for the localized effects at the site of their application by virtue of drug penetration into the underlying layers of skin or mucous membranes lionberger and brennan, 2010. Topical foam vehicles are innovative alternatives to creams and ointments, addressing many patient challenges with traditional vehicles. Use the lowest effective dosage for the shortest duration consistent with individual patient.
There is no marketed topical formulation of mefenamic acid available till date. Deshmuk vidyabharti college of pharmacy, amravati, camp road, amravati, maharshtra, india abstract aim. The f 9 and f 10 formulations with hpmc lost uniform gel characteristics right after the addition of extract. Solvents like glycerin and propylene glycol can alter rheology and drug delivery characteristics of topical gels owing to their different viscosities and due to the change in solventpolymer and solventsolvent interactions. Thus the gel developed was evaluated for various physicochemical parameters like its physical. Recent advances in topical gel formulation department of pharmaceutics, nirmala college of pharmacy, muvattupuzha, ernakulam, kerala, india transdermal drug delivery systems are a constant source of interest because of the benefits that they afford in overcoming many drawbacks associated with other modes of drug delivery i. Gel form of m3 and m4 were prepared using 1% carbopol 940 as the hydrogel matrix. The formulations were evaluated for the physicochemical and release characteristics. Basf offers broad portfolio of excipients for topical formulations enabling you to create the ideal skin delivery solution for your gel formulation.
Development and evaluation of ibuprofen transdermal gel. Pdf formulation and evaluation of topical nano emulgel. At the same time, we have focused on improving the mildness of formulations. The present investigation involves formulation of acelofenac topical gel having linseed oil and piparine. Aceclofenac has been shown to have potent analgesic and antiinflammatory activities. Development and evaluation of ibuprofen transdermal gel formulations bazigha k abdul rasool 1, eman f abugharbieh 1, sahar a fahmy 2, heyam s saad 1 and saeed a khan 1 1dubai pharmacy college, dubai, uae, 2helwan university, helwan, egypt abstract purpose. Research article formulation and evaluation of ibuprofen topical gel. Twelve herbal gel formulations were prepared using 1. The reference gives a beyonduse date of 1 year, but the warning of periodically observing the formulation for signs of physical instability. Development and evaluation of stability of a gel formulation. Va pharmacy benefits management prescription claims data suggest that the gel is the most. It can be concluded that luliconazole microemulgel prepared with linseed oil and sodium alginate can be a choice for topical antifungal treatment. Research article preparation and evaluation of topical gel of. The aims of this study were to develop liposome enriched.
Both formulations were evaluated in the liquid and gel forms for drug retention in the skin in comparison to the marketed ctm topical cream and their stability examined after storage at 40c for 6 months. Formulation and evaluation of topical aceclofenac gel using. Design, formulation and evaluation of an oral gel from. Other formulations f 4, f 5 and f 6 were completely uniform with no bubbles and no lumps when touched. Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model rajasekaran aiyalu, arulkumaran govindarjan, arivukkarasu ramasamy kmch college of pharmacy, coimbatore, tamilnadu, india the objective of the study is to formulate and evaluate a topical herbal gel containing cardiospermum. This formulation will be preserved due to the very high alcohol concentration. To develop an ibuprofen transdermal gel with a capability for both topical and systemic. Nano emulgel emerged as one of the most interesting topical drug delivery. Formulation and evaluation of topical gel authorstream.
Creams and emulsions are the most diverse and widely used dosage forms for topical dermatological applications. Quality by design qbd for topical dermatologic products. As a result, the therapeutics effects of the drugs are. Pdf formulation and evaluation of hair gel for the. Pdf topical gels of valdecoxib topical gel prepared using different gelling agents viz, carbopol, hpmc, sodium alginate, sodium cmc.
Formulation and evaluation of diclofenac transdermal gel. The present invention provides a stable gel formulation for topical treatment of skin conditions in humans. Nov 03, 2016 spreadability of semisolid formulations, that is, the ability of a cream or gel to evenly spread on the skin, plays an important role in the administration of a standard dose of a medicated formulation to the skin and the efficacy of a topical therapy. Formulation and evaluation of antibacterial creams and gels. Pdf formulation and evaluation of topical nano emulgel of. So the present study, formulation and evaluation of diclofenac sodium transdermal gel will attempt to. It is used in the treatment of superficial candidiasis, dermatophysis and pityriasis versicolor. Formulation and evaluation of mefenamic acid emulgel for. Aqueous gels with different ph were prepared by dissolv.
They are twophase systems typically containing hydrophilic ingredient in an aqueous phase and lipophilic ingredients in an oil phase. The drug release from all gelling agents through a standard cellophane membrane was evaluated using. International journal of research pharmaceutical and nano. Formulation and evaluation of topical gel using eupatorium glandulosum michx.
Goyal department of pharmaceutics, isf college of pharmacy, moga, punjab abstract skin is the largest organ of the human body and plays the most important role in protecting against pathogen and foreign matter. Gel formulation provides better application property and stability in comparison to cream and ointments. The current study was designed to develop a topical gel formulation containing the monoterpene borneol using carbopol as gel base and to evaluate its stability. Rheological characterization of topical carbomer gels. Journal of pharmaceutical quality assurance topical gel formulation. The topical gel formulation offers an interesting alternative for achieving systemic drug effects of parental routes, which can be inconvenient for oral route, which can result in nausea, vomiting, low bioavailability and passes the hepatic firstpass metabolism. A cream formulation for topical application to an external portion of a human body. A one ounce preparation of such cream formulation includes active ingredients consisting essentially of a predetermined weight of an aloe vera gel compound present in the topical formulation generally in a weight range of between about 3 grams and about 10 grams.
Pdf preparation and evaluation of topical gel of valdecoxib. Pulla reddy college of pha rmacy, osmania university, hyderabad, andhra pradesh, india. Us5914334a stable gel formulation for topical treatment of. Benzaclin topical gel was studied in male and female patients n with acne vulgaris. Among all the gel formulations, carbopol showed superior drug release than followed by na cmc, hpmc and sodium alginate.
The stable gel formulation includes an active agent, having activity for treatment of acne and psoriasis, which is insoluble in water and a plurality of nonaqueous vehicles for both solubilizing said active agent and forming a gel therewith enabling topical application of the gel to a. Spreadability of semisolid formulations, that is, the ability of a cream or gel to evenly spread on the skin, plays an important role in the administration of a standard dose of a medicated formulation to the skin and the efficacy of a topical therapy. Approximately 18% alcohol usp will preserve a formulation. Topical gel formulation provides a suitable delivery system for drugs because they are less greasy and can be easily removed from the skin.
The gel formulation was designed by using methanolic extract of leaves of c alata and c tora and aerial part of c. Jul 02, 2011 gel form of m3 and m4 were prepared using 1% carbopol 940 as the hydrogel matrix. Benzaclin topical gel food and drug administration. The aim of the present research work is to decrease the systemic side effects and to create a more pronounced effect of nano emulgel of adapalene with lower doses of the drug. The topical drug delivery system is simple, effective and very useful in treating acne. Formulation and evaluation of topical herbal gel for the. Formulation and evaluation of topical gel using eupatorium. The aim of this work was to prepare and evaluate the topical carbopol gel formulation containing ketoconazole encapsulated liposomes. Abstract gel formulation provides better application property and stability in comparison to cream and ointment. Department of pharmaceutics and industrial pharmacy, faculty of pharmacy, modern university for technology and info rmation, cairo.